Preliminary characterization of N-trimethylchitosan as a nanocarrier for malarie vaccine

Preliminary characterization of N-trimethylchitosan as a nanocarrier for malarie vaccine

Vaccination is considered to be most effective way of fighting infectious diseases like malaria etc [1]. N, N, N-trimethylchitosan (TMC) was synthesized from chitosan. Nanoparticles of the TMC were prepared in various media (milliQ water, Na2CO3 (pH 10.92), Na2HPO4 (pH 9.01) and alhydrogel beads which were characterized as adjuvant for possible vaccine delivery. The nanoparticles were analyzed ...

Preliminary characterization of N-trimethylchitosan as a nanocarrier for malaria vaccine.

BACKGROUND & OBJECTIVES With the current snags from the use of Artemisinin - combination therapies (ACTs) in malaria treatment in addition to fear of cross- resistance to unrelated drugs, raising the immunocompetence of individuals in malaria endemic areas by vaccination is the best approach to malaria - free world. METHODS Water - soluble cationic derivative, N, N, N- trimethylchitosan (TMC)...

Preparation, in-vitro characterization and pharmacokinetic evaluation of Brij decorated doxorubicin liposomes as a potential nanocarrier for cancer therapy

The aim of current study was to investigate the effect of Brij decoration of liposomes on in vitro and in vivo characteristics of the nanocarriers. Two hydrophilic Brij surfactants (Brij 35 and Brij 78) with almost similar molecular weight but differing in acyl chain were incorporated into liposomal bilayers at two percentages (5% and 10%). Conventional liposomes (CL) containing egg phosphatidy...

Preparation, in-vitro characterization and pharmacokinetic evaluation of Brij decorated doxorubicin liposomes as a potential nanocarrier for cancer therapy

The aim of current study was to investigate the effect of Brij decoration of liposomes on in vitro and in vivo characteristics of the nanocarriers. Two hydrophilic Brij surfactants (Brij 35 and Brij 78) with almost similar molecular weight but differing in acyl chain were incorporated into liposomal bilayers at two percentages (5% and 10%). Conventional liposomes (CL) containing egg phosphatidy...

synthesis and characterization of linear-dendritic of peg and citric acid as a nanocarrier for tamoxifen